GAMMA GLOBULIN TURNOVER AND INTESTINAL DEGRADATION OF GAMMA GLOBULIN IN THE DOG*

Gamma Globulin Turnover and Intestinal Degradation of Gamma Globulin in the Dog.

Increased catabolism of plasma proteins by leakage into the gastrointestinal tract and subsequent digestion by the intestinal enzymes are frequently the causes of hypoproteinemia (1-5). The presence of plasma proteins has been demonstrated both in saliva and in the gastric and intestinal juice of normal individuals; therefore, gastrointestinal leakage of plasma proteins may account for a substa...

Gamma Globulin Turnover in Rabbits before and during Hyperimmunization

The turnover of (131)I-labeled gamma globulin has been determined in rabbits before and during (8 weeks later) hyperimmunization with pneumococcic vaccine, which increased the gamma globulin concentration 5 to 10 times. Before immunization fractional turnover rate was an average of 36 per cent of the plasma pool per day, and the rate of catabolism was 133 mg/kg/day. During hyperimmunization fra...

Human Gamma Globulin.

Gamma globulin prophylaxis.

THE importance of infectious hepatitis as a world-wide problem has been highlighted in detail during the presentations made at this symposium. It is clear that as of today (May I 8, I968) there is no published report confirming the isolation of infectious hepatitis virus in a tissue-culture system or animal host. Experience with poliomyelitis, measles, and rubella has revealed that the time int...

Purification of rat gamma globulin and the production of a specific antirat gamma globulin serum.

A method for the isolation of rat 7S gamma globulin based on multiple adsorptions with DEAE-Sephadex A-50 has been presented. The separation of rat 7S globulin requires a procedure modified from the one used for humans in terms of the buffer pH, and the number of adsorptions. Ultracentrifugal analysis indicates the resulting fraction is a single component. In addition, immunoelectrophoresis of ...